Publications

2025
David AP, Biswas S, Soltis MP, Eltawil Y, Zhou R, Easow SA, Cheng AG, Heller S, Jan TA. Crosstalk signaling between the epithelial and non-epithelial compartments of the mouse inner ear.  J Assoc Res Otolaryngol. 2025 Mar 13. doi: 10.1007/s10162-025-00980-7. Epub ahead of print. PMID: 40080263. (cover image)

2024
DeFreese A, Berg K, Noble J, Dawant B, Holder J, Amberg S, Brown C, Burg E, Dwyer N, Sisler-Dinwiddie A, Sparrow T, Sunderhaus L, Yaras S, Bennett M, Jan T, Moberly A, O'Malley M, Patro A, Perkins E, Tawfik K, Haynes D, Gifford R. Frequency-to-Place Mismatch and Cochlear Implant Outcomes by Electrode Type. JAMA Otolaryngol Head Neck Surg. 2024 Dec 12. doi: 10.1001/jamaoto.2024.4158. Epub ahead of print. PMID: 39666319.

Freeman MH, Patro A, Lindquist NR, Berg KA, Holder JT, O'Malley MR, Tawfik KO, Jan TA, Perkins EL, Moberly AC, Haynes DS, Bennett ML. Patient Preferences in Cochlear Implant Manufacturer Selection. Otol Neurotol. 2024 Nov 21. Epub ahead of print. PMID: 39627903.

Patro A, Moberly AC, Freeman MH, Perkins EL, Jan TA, Tawfik KO, O'Malley MR, Bennett ML, Gifford RH, Haynes DS, Chowdhury NI. Investigating the Minimal Clinically Important Difference for AzBio and CNC Speech Recognition Scores. Otol Neurotol. 2024 Oct 1;45(9):e639-e643. PMID: 39264921.

Camalan S, Langefeld CD, Zinnia A, McKee B, Carlson ML, Deep NL, Harris MS, Jan TA, Kaul VF, Lindquist NR, Mattingly JK, Shah J, Zhan KY, Gurcan MN, Moberly AC. Digital Otoscopy With Computer-Aided Composite Image Generation: Impact on the Correct Diagnosis, Confidence, and Time. Otolaryngol Head Neck Surg. 2024 Sep 2. doi: 10.1002/ohn.965. Epub ahead of print. PMID: 39221462.

Wang T, Ling AH, Billings SE, Hosseini DK, Vaisbuch Y, Kim GS, Atkinson PJ, Sayyid ZN, Aaron KA, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore LS, Maria PS, Blevins NH, Jackler RK, Alyono JC, Kveton J, Navaratnam D, Heller S, Lopez IA, Grillet N, Jan TA*, Cheng AG*. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs. Nat Commun. 2024 Jun 6;15(1):4833. doi: 10.1038/s41467-024-48491-y. PMID: 38844821; PMCID: PMC11156867. (*corresponding authors)

Benkafadar N, Sato MP, Ling AH, Janesick A, Scheibinger M, Jan TA, Heller S. An essential signaling cascade for avian auditory hair cell regeneration. Dev Cell. 2024 Jan 22;59(2):280-291.e5. doi: 10.1016/j.devcel.2023.11.028. PMID: 38128539.

2023
Okhovat M, VanCampen J, Nevonen KA, Harshman L, Li W, Layman CE, Ward S, Herrera J, Wells J, Sheng RR, Mao Y, Ndjamen B, Lima AC, Vigh-Conrad KA, Stendahl AM, Yang R, Fedorov L, Matthews IR, Easow SA, Chan DK, Jan TA, Eichler EE, Rugonyi S, Conrad DF, Ahituv N, Carbone L. TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function. Nat Commun. 2023 Dec 7;14(1):8111. doi: 10.1038/s41467-023-43841-8. PMID: 38062027.

2022
David AP, Loftus PA, Russell MS, Goldberg AN, El-Sayed IH, Jan TA, Roland LT. RNA Sequencing and Gene Ontology Analysis in Acute Invasive Fungal Sinusitis. Am J Rhinol Allergy. 2023 Jan;37(1):78-82. doi: 10.1177/19458924221134732. Epub 2022 Oct 26. PMID: 36285477

Scheibinger M, Janesick A, Benkafadar N, Ellwanger DC, Jan TA, Heller S. Cell-type identity of the avian utricle. Cell Rep. 2022 Sep 27;40(13):111432. doi: 10.1016/j.celrep.2022.111432. PMID: 36170825.

Landegger LD, Fujita T, Jan TA, Varela-Nieto I. Editorial: Otologic Trauma, Pathology, and Therapy. Front Cell Neurosci. 2022 Apr 13;16:900074. doi: 10.3389/fncel.2022.900074. PMID: 35496907.

2021
Jan TA, Eltawil Y, Ling AH, Chen L, Ellwanger DC, Heller S, Cheng AG. Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics. Cell Rep. 2021 Jul 13;36(2):109358. doi: 10.1016/j.celrep.2021.109358. PMID: 34260939.

Benkafadar N, Janesick A, Scheibinger M, Ling AH, Jan TA, Heller S. Transcriptomic characterization of dying hair cells in the avian cochlea. Cell Rep. 2021 Mar 23;34(12):108902. doi: 10.1016/j.celrep.2021.108902. PMID: 33761357.

Kubota M, Scheibinger M, Jan TA, Heller S. Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea. Cell Rep. 2021 Jan 19;34(3):108646. doi: 10.1016/j.celrep.2020.108646. PMID: 33472062.

2020
Kozin ED, Remenschneider AK, Blevins NH, Jan TA, Quesnel AM, Chari DA, Kesser BW, Weinstein JE, Ahsan SF, Telischi FF, Adunka OF, Weber P, Knoll RM, Coelho DH, Anne S, Franck KH, Marchioni D, Barker FG 2nd, Carter BS, Lustig LR, Bojrab DI, Bhansali SA, Westerberg BD, Lundy L, Jackler RK, Roland JT Jr, Chandrasekhar SS, Antonelli PJ, Carey JP, Welling DB, Slattery WH 3rd, Lee DJ; members of the American Neurotology Society Council, members of the American Otological Society Council, and members of the American Academy of Otolaryngology – Head and Neck Surgery Hearing Committee and Implantable Hearing Devices Committee. American Neurotology Society, American Otological Society, and American Academy of Otolaryngology - Head and Neck Foundation Guide to Enhance Otologic and Neurotologic Care During the COVID-19 Pandemic. Otol Neurotol. 2020 Oct;41(9):1163-1174. doi: 10.1097/MAO.0000000000002868. PMID: 32925832.

Jan TA, Cheng AG, Jackler RK. Cummings Otolaryngology: Head & Neck Surgery. Congenital malformations of the inner ear. 2020. 

2019
Jackler RK, Jan TA. The future of otology. J Laryngol Otol. 2019 Sep;133(9):747-758. doi: 10.1017/S0022215119001531. Epub 2019 Aug 29.  PMID: 31462337.

2017
Jan TA, Remenschneider AK, Halpin C, Seton M, McKenna MJ, Quesnel AM. Third-generation bisphosphonates for cochlear otosclerosis stabilizes sensorineural hearing loss in long-term follow-up. Laryngoscope Investig Otolaryngol. 2017 Sep 21;2(5):262-268. doi: 10.1002/lio2.91. PMID: 29094069.

Gadkaree SK, Jan TA, Quesnel AM. Pneumatocele of the Tympanic Membrane. Otol Neurotol. 2017 Apr;38(4):e19-e20. doi: 10.1097/MAO.0000000000001363. PMID: 28198720.

Jan TA, Cheng YS, Landegger LD, Lin BM, Srikanth P, Niesten ME, Lee DJ. Relationship between Surgically Treated Superior Canal Dehiscence Syndrome and Body Mass Index. Otolaryngol Head Neck Surg. 2017 Apr;156(4):722-727. doi: 10.1177/0194599816686563. Epub 2017 Jan 24. PMID: 28116976.

Jan TA, Lee DJ. Operative Techniques in Otolaryngology-Head and Neck Surgery 28 (1), 11-16. Transcanal endoscopic tympanotomy. 2017; 28(1):11-16.

2016
Jan TA, Kozin ED, Kanumuri VV, Sethi RK, Jung DH. Improvement in word recognition following treatment failure for sudden sensorineural hearing loss. World J Otorhinolaryngol Head Neck Surg. 2016 Nov 24;2(3):168-174. doi: 10.1016/j.wjorl.2016.06.002. PMID: 29204563.

Jan TA, Jansson L, Atkinson PJ, Wang T, Cheng AG. Profiling Specific Inner Ear Cell Types Using Cell Sorting Techniques. Methods Mol Biol. 2016;1427:431-45. doi: 10.1007/978-1-4939-3615-1_23. PMID: 27259940.

2014
Liu YM, Ibrahim A, Jan T, Chang P, Fagan S, Goverman J. Skin necrosis as a complication of therapeutic hypothermia. J Burn Care Res. 2014 May-Jun;35(3):e184-6. doi: 10.1097/BCR.0b013e3182a22730. PMID: 24043239.

2013
Volkenstein S, Oshima K, Sinkkonen ST, Corrales CE, Most SP, Chai R, Jan TA, van Amerongen R, Cheng AG, Heller S. Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14456-61. doi: 10.1073/pnas.1307376110. PMID: 23940359.

Herget M, Scheibinger M, Guo Z, Jan TA, Adams CM, Cheng AG, Heller S. A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis. PLoS One. 2013 Jun 4;8(6):e66026. doi: 10.1371/journal.pone.0066026. PMID: 23750277.

Jan TA, Redjal N, Walcott BP, Sheth SA. Intranasal myiasis: a rare complication of transnasal skull base surgery. J Clin Neurosci. 2013 Aug;20(8):1178-80. doi: 10.1016/j.jocn.2012.09.028. Epub 2013 May 10. PMID: 23669173.

Jan TA, Chai R, Sayyid ZN, van Amerongen R, Xia A, Wang T, Sinkkonen ST, Zeng YA, Levin JR, Heller S, Nusse R, Cheng AG. Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development. 2013 Mar;140(6):1196-206. doi: 10.1242/dev.087528. PMID: 23444352.

2012
Chan DK, Jan TA, Koltai PJ. Effect of obesity and medical comorbidities on outcomes after adjunct surgery for obstructive sleep apnea in cases of adenotonsillectomy failure. Arch Otolaryngol Head Neck Surg. 2012 Oct;138(10):891-6. doi: 10.1001/2013.jamaoto.197. PMID: 23069817.

Chai R, Kuo B, Wang T, Liaw EJ, Xia A, Jan TA, Liu Z, Taketo MM, Oghalai JS, Nusse R, Zuo J, Cheng AG. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8167-72. doi: 10.1073/pnas.1202774109. Epub 2012 May 4. PMID: 22562792.

2011
Jan TA, Chai R, Sayyid ZN, Cheng AG. Isolating LacZ-expressing cells from mouse inner ear tissues using flow cytometry. J Vis Exp. 2011 Dec 23;(58):e3432. doi: 10.3791/3432. PMID: 22217925.

Sinkkonen ST, Chai R, Jan TA, Hartman BH, Laske RD, Gahlen F, Sinkkonen W, Cheng AG, Oshima K, Heller S. Intrinsic regenerative potential of murine cochlear supporting cells. Sci Rep. 2011;1:26. doi: 10.1038/srep00026. Epub 2011 Jun 29. PMID: 22355545.

Chai R, Xia A, Wang T, Jan TA, Hayashi T, Bermingham-McDonogh O, Cheng AG. Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. J Assoc Res Otolaryngol. 2011 Aug;12(4):455-69. doi: 10.1007/s10162-011-0267-2. Epub 2011 Apr 7. PMID: 21472479.

Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Robbins RC, Wu JC. Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest. 2011 Mar;121(3):1217-21. doi: 10.1172/JCI44635. Epub 2011 Feb 7. PMID: 21317531.

Lieberman DM, Jan TA, Ahmad SO, Most SP. Effects of corticosteroids on functional recovery and neuron survival after facial nerve injury in mice. Arch Facial Plast Surg. 2011 Mar-Apr;13(2):117-24. doi: 10.1001/archfacial.2010.98. Epub 2010 Nov 15. PMID: 21079107.

2008
Reiner DJ, Jan TA, Boughter JD Jr, Li CX, Lu L, Williams RW, Waters RS. Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice. Chem Senses. 2008 Oct;33(8):693-707. doi: 10.1093/chemse/bjn025. Epub 2008 Jul 24. PMID: 18653645.

Walker WB, Smith EM, Jan T, Zwiebel LJ. A functional role for Anopheles gambiae Arrestin1 in olfactory signal transduction. J Insect Physiol. 2008 Apr;54(4):680-90. doi: 10.1016/j.jinsphys.2008.01.007. Epub 2008 Feb 3. PMID: 18328499.

Jan TA, Lu L, Li CX, Williams RW, Waters RS. Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice. BMC Neurosci. 2008 Jan 7;9:3. doi: 10.1186/1471-2202-9-3. PMID: 18179704.

2007
Oladehin A, Margret CP, Maier SE, Li CX, Jan TA, Chappell TD, Waters RS. Early postnatal alcohol exposure reduced the size of vibrissal barrel field in rat somatosensory cortex (SI) but did not disrupt barrel field organization. Alcohol. 2007 Jun;41(4):253-61. doi: 10.1016/j.alcohol.2007.04.005. PMID: 17630086.

2006
Margret CP, Chappell TD, Li CX, Jan TA, Matta SG, Elberger AJ, Waters RS. Prenatal alcohol exposure (PAE) reduces the size of the forepaw representation in forepaw barrel subfield (FBS) cortex in neonatal rats: relationship between periphery and central representation. Exp Brain Res. 2006 Jul;172(3):387-96. doi: 10.1007/s00221-005-0339-9. Epub 2006 Jan 20. PMID: 16424976.