1. Mitotic regeneration in the inner ear: Using an in vivo hair cell ablation model combined with single cell RNA seq and lineage tracing experiments, we aim to gain an in-depth understanding of mitotic hair cell and supporting cell regeneration.
2. Development: We seek to learn the developmental cues that are responsible for patterning of the inner ear organs. Our goal is to determine how we can use developmental cues to arrive at regenerative therapies.
3. Application of computational tools: We seek to apply the latest computational and multi-omics tools to answer fundamental questions of development and regeneration within the inner ear across multiple species.
4. Translational: We are interested in leveraging our ability to access human inner ear tissues with cutting edge discoveries made in our mammalian mouse models.
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