1. Mitotic regeneration in the inner ear: Using an in vivo hair cell ablation model combined with single cell RNA seq and lineage tracing experiments, we aim to gain an in-depth understanding of mitotic hair cell and supporting cell regeneration.
2. Development: We seek to learn the developmental cues that are responsible for patterning of the inner ear organs. Our goal is to determine how we can use developmental cues to arrive at regenerative therapies.
3. In vivo inner ear injury model development: We look to develop an in vivo viral injury model and leverage single cell RNA seq tools to study the inner ear's response to injury.
4. Translational: We are interested in leveraging our ability to access human inner ear tissues with cutting edge discoveries made in our mammalian mouse models.
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